Sample Collection: What impact does GLP-1 receptor agonists (e.g Ozempic and Mounjaro) have on Microbiome Explorer test results?

GLP-1 receptor agonists may indirectly influence results by altering gut physiology.
​
- These drugs slow gastric emptying, modulate bile acid levels, and change nutrient intake, all of which can affect microbial populations.
- They do not interfere with DNA extraction, PCR, or sequencing.
- GLP-1 RAs may affect gut inflammation, motility, or secretion, which could influence some GI and microbial marker results.
- If GI side effects occur (e.g., diarrhoea), markers such as calprotectin may be altered.
- Always record GLP-1RA use on requisition forms or clinician notes to support accurate interpretation.
​
​https://doi.org/10.1210/clinem/dgae719

https://doi.org/10.3390/nu17081303

10.1016/s2468-1253(24)00188-2

10.14309/ctg.0000000000000815

https://doi.org/10.3389/fnut.2025.1566498